Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents.
نویسندگان
چکیده
A series of novel dithiocarbamates with benzimidazole and chalcone scaffold have been designed synthesised and evaluated for their antimitotic activity. Compounds 4c and 9d display the most promising antimitotic activity with IC(50) of 1.66 μM and 1.52 μM respectively.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 22 9 شماره
صفحات -
تاریخ انتشار 2012